お問い合わせ

2011年

業績目録

原著

  1. Alternative synthesis of radioiodinated trisaccharide derivatives, 2-(4-125Iodophenyl)ethyl 2-acetamido-2-deoxy-β-d-glucopyranosyl-(1→2)-α-D-mannopyranosyl-(1→6)-β-D-glucopyranoside, and preparation of its analogs having different lengths of alkyl chains instead of ethyl group: Acceptor substrates of N-acetylglucosaminyltransferase V for in vivo imaging. Kenji Arimitsu, Tetsuya Kajimoto, Hiroyuki Kimura, Masahiro Ono, Minoru Ozeki, Manabu Node, Yoshiro Ohmomo, Hideo Saji, Masayuki Yamashita. Heterocycles, 83(12), 2779-2802 (2011)
  2. Effective synthesis of 99mTc tricarbonyl complexes by microwave heating. Naoya Harada, Hiroyuki Kimura, Masahiro Ono, Daisuke Mori, Yoshiro Ohmomo, Tetsuya Kajimoto, Hidekazu Kawashima, Hideo Saji. Journal of Organometallic Chemistry, 696(23), 3745-3749 (2011)
  3. A dual fluorinated and iodinated radiotracer for PET and SPECT imaging of b-amyloid plaques in the brain. Hiroyuki Watanabe, Masahiro Ono, Hiroyuki Kimura, Shinya Kagawa, Ryuichi Nishii, Takeshi Fuchigami, Mamoru Haratake, Morio Nakayama, Hideo Saji. Bioorganic & Medicinal Chemistry Letters, 21(21), 6519-6522 (2011)
  4. Effective encapsulation of a new cationic gadolinium chelate into apoferritin and its evaluation as an MRI contrast agent. Akira Makino, Hiroshi Harada, Tomohisa Okada, Hiroyuki Kimura, Hiroo Amano, Hideo Saji, Masahiro Hiraoka, Shunsaku Kimura. Nanomedicine: Nanotechnology, Biology and Medicine, 7(5), 638-646 (2011)
  5. Synthesis and evaluation of a radioiodinated trisaccharide derivatives as a synthetic substrate for a sensitive N-acetylglucosaminyltransferase V radioassay. Takahiro Mukai, Masayori Hagimori, Kenji Arimitsu, Takahiro Katoh, Misa Ukon, Tetsuya Kajimoto, Hiroyuki Kimura, Yasuhiro Magata, Eiji Miyoshi, Naoyuki Taniguchi, Manabu Node, Hideo Saji. Bioorganic & Medicinal Chemistry, 19(14), 4312-4321 (2011)
  6. Novel quinoxaline derivatives for in vivo imaging of b-amyloid plaques in the brain. Mengchao Cui, Masahiro Ono, Hiroyuki Kimura, Boli Liu, Hideo Saji. Bioorganic & Medicinal Chemistry Letters, 21(14), 4193-4196 (2011)
  7. Synthesis and evaluation of benzofuran-2-yl(phenyl)methanone derivatives as ligands for b-amyloid plaques. Mengchao Cui, Masahiro Ono, Hiroyuki Kimura, Boli Liu, Hideo Saji. Bioorganic & Medicinal Chemistry, 19(13), 4148-4153 (2011)
  8. Concise site-specific synthesis of DTPA-peptide conjugates: Application to imaging probes for the chemokine receptor CXCR4. Ryo Masuda, Shinya Oishi, Hiroaki Ohno, Hiroyuki Kimura, Hideo Saji, Nobutaka Fujii. Bioorganic & Medicinal Chemistry, 19(10), 3216-3220 (2011)
  9. Phenyldiazenyl benzothiazole derivatives as probes for in vivo imaging of neurofibrillary tangles in Alzheimer’s disease brains. Kenji Matsumura, Masahiro Ono, Shun Hayashi, Hiroyuki Kimura, Yoko Okamoto, Masafumi Ihara, Ryosuke Takahashi, Hiroshi Mori, Hideo Saji. MedChemComm, 2(7), 596-600 (2011)
  10. Novel 18F-labeled benzofuran derivatives with improved properties for positron emission tomography (PET) imaging of b-amyloid plaques in Alzheimer’s brains. Masahiro Ono, Yan Cheng, Hiroyuki Kimura, Mengchao Cui, Shinya Kagawa, Ryuichi Nishii, Hideo Saji. Journal of Medicinal Chemistry, 54(8), 2971-2979 (2011)
  11. Synthesis and structure-affinity relationships of novel dibenzylideneacetone derivatives as probes for b-amyloid plaques. Mengchao Cui, Masahiro Ono, Hiroyuki Kimura, Boli Liu, Hideo Saji. Journal of Medicinal Chemistry, 54(7), 2225-2240 (2011)
  12. Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer’s brains. Masahiro Ono, Shun Hayashi, Kenji Matsumura, Hiroyuki Kimura, Yoko Okamoto, Masafumi Ihara, Ryosuke Takahashi, Hiroshi Mori, Hdeo Saji. ACS Chemical Neuroscience, 2(5), 269-275 (2011)
  13. Synthesis and biological evaluation of indole-chalcone derivatives as b-amyloid imaging probe. Mengchao Cui, Masahiro Ono, Hiroyuki Kimura, Bo Li Liu, Hideo Saji. Bioorganic & Medicinal Chemistry Letters, 21(3), 980-982 (2011)
  14. Radioiodinated benzimidazole derivatives as single photon emission computed tomography probes for imaging of b-amyloid plaques in Alzheimer’s disease. Mengchao Cui, Masahiro Ono, Hiroyuki Kimura, Hidekazu Kawashima, Bo Li Liu, Hideo Saji. Nuclear Medicine and Biology, 38(3), 313-320 (2011)
  15. Preparation and evaluation of a radiogallium complex-conjugated bisphosphonate as a bone scintigraphy agent. Kazuma Ogawa, Kenichiro Takai, Hiroya Kanbara, Tatsuto Kiwada, Yoji Kitamura, Kazuhiro Shiba, Akira Odani. Nuclear Medicine and Biology, 38, 631-636 (2011), 10.1016/j.nucmedbio.2010.12.004.
  16. Antitumor Agents. 284: New Desmosdumotin B Analogues with Bicyclic B-Ring as Cytotoxic and Antitubulin Agents. Kyoko Nakagawa-Goto, Pei-Chi Wu, Chin-Yu Lai, Ernest Hamel, Hao Zhu, Liying Zhang, Takashi Kozaka, Emika Ohkoshi, Masuo Goto, Kenneth F Bastow, Kuo-Hsiung Lee. Journal of Medicinal Chemistry, 54, 1244-1255 (2011), 10.1021/jm1011947.

国際及び国内学会発表

  1. Hiroyuki Kimura (oral), Yu Ogawa, Hidekazu Kawashima, Kentaro Toyoda, Eri Mukai, Hiroyuki Fujimoto, Konomu Hirao, Masahiro Ono, Nobuya Inagaki, Hideo Saji, Synthesis and evaluation of [18F]Exendin-4 derivatives as a PET tracer for measuring β-cell mass in pancreatic islets, AIMECS 2011, Keio Plaza Hotel, Tokyo, Tue 29 November – Fri 2 December 2011
  2. Hiroyuki Kimura (poster), Hidekazu Saiki, Ren Iwata, Eiichi Ozeki, Masahiro Ono, Hideo Saji, One-Flow Synthesis of [18F]SFB Using Fully Automated Microreactor-based Continuous Flow System, 19th International Symposium on Radiopharmaceutical Sciences, Amsterdam, The Netherlands, August 28 – September 2, 2011
  3. Hiroyuki Kimura (oral), Yu Ogawa, Hidekazu Kawashima, Kentaro Toyoda, Eri Mukai, Hiroyuki Fujimoto, Masahiro Ono, Konomu Hirao, Nobuya Inagaki, Hideo Saji, Synthesis and evaluation of F-18 Exendin-4 derivatives for the imaging of GLP-1 receptor expression in pancreatic islets, Society of Nuclear Medicine 58th Annual Meeting, San Antonio, Texas, June 4-8, 2011

その他の印刷物(解説、プロシーディング等)

解説

  1. 株木重人，谷森達，木村寛之．電子飛跡検出型コンプトンカメラが導くイメージング技術の未来, 「画像情報メディカル」, 43巻13号：1100-1104 (2011)
  2. 谷森達，株木重人，木村寛之．電子飛跡検出型コンプトンカメラによる新しいイメージング診断手法,「PETジャーナル」, 第16号（2011)
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