お問い合わせ

2016年

業績目録(木村 寛之)

原著

  1. Radiosynthesis of novel pitavastatin derivative ([18F]PTV-F1) as a tracer for hepatic OATP using a One-Pot synthesis procedure. Hiroyuki Kimura*, Yusuke Yagi, Kenji Arimitsu, Kazuya Maeda, Kazuaki Ikejiri, Jun-ichi Takano,Hiroyuki Kusuhara, Shinya Kagawa, Masahiro Ono, Yuichi Sugiyama, Hideo Saji. Journal of Labelled Compounds and Radiopharmaceuticals, 59(13), 565-575 (2016)
  2. Continuous-flow synthesis of N-succinimidyl 4-[18F]fluorobenzoate using a single microfluidic chip. Hiroyuki Kimura*, Kenji Tomatsu, Hidekazu Saiki, Kenji Arimitsu, Masahiro Ono, Hidekazu Kawashima, Ren Iwata, Hiroaki Nakanishi, Eiichi Ozeki, Yuji Kuge, Hideo Saji. PLOS ONE, 11, e0159303 (2016)
  3. Synthesis and biological evaluation of novel 18F-labeled probes targeting prostate-specific membrane antigen for positron emission tomography of prostate cancer. Naoya Harada, Hiroyuki Kimura, Satoru Onoe, Hiroyuki Watanabe, Daiko Matsuoka, Kenji Arimitsu, Masahiro Ono, Hideo Saji. Journal of Nuclear Medicine, 57(12), 1978-1984 (2016)
  4. Development of 99mTc-labeled pyridyl benzofuran derivatives to detect pancreatic amylin in islet amyloid model mice. Masashi Yoshimura, Masahiro Ono, Hiroyuki Watanabe, Hiroyuki Kimura, Hideo Saji. Bioconjugate Chem, 27, 1352-1539 (2016)
  5. Imaging of cerebral amyloid angiopathy with bivalent 99mTc-hydroxamide complexes. Shimpei Iikuni, Masahiro Ono, Hiroyuki Watanabe, Kenji Matsumura, Masashi Yoshimura, Hiroyuki Kimura, Hatsue Ishibashi-Ueda, Yoko Okamoto, Masafumi Ihara, Hideo Saji. Scientific Reports, 6, 25990 (2016)
  6. Synthesis and preliminary characterization of radioiodinated benzofuran-3-yl-(indol-3-yl)maleimide derivatives as SPECT imaging probes for the detection of glycogen synthase kinase-3b (GSK-3b) in the brain. Masahiro Ono, Ayane Kitada, Hiroyuki Watanabe, Anna Miyazaki, Hiroyuki Kimura, Hideo Saji. Journal of Labelled Compounds and Radiopharmaceuticals, 59(8), 317-321 (2016)
  7. Development of 99mTc-labeled asymmetric urea derivatives that target prostate-specific membrane antigen for single-photon emission computed tomography imaging. Hiroyuki Kimura, Sotaro Sampei, Daiko Matsuoka, Naoya Harada, Hiroyuki Watanabe, Kenji Arimitsu, Masahiro Ono, Hideo Saji. Bioorganic & Medicinal Chemistry, 24(10), 2251-2256 (2016)
  8. A novel CYP11B2-specific imaging agent for detection of unilateral subtypes of primary aldosteronism. Tsutomu Abe, Mitsuhide Naruse, William F Young Jr., Nobuya Kobashi, Yoshihiro Doi,Akihiro Izawa, Kei Akama, Yuki Okumura, Miho Ikenaga, Hiroyuki Kimura, Hideo Saji,Kuniaki Mukai, Hiroki Matsumoto.The Journal of Clinical Endocrinology & Metabolism, 101(3):1008-1015 (2016)
  9. 18F-Containig positron emission tomography probe conjugation methodology for biologics as specific binders for tumors. Kenji Arimitsu, Hiroyuki Kimura, Yoshinari Arai, Kazuto Mochizuki, Masumi Taki. Current Topics in Medicinal Chemistry, 16, 2703-2724 (2016)
  10. Evaluation of tumor-associated stroma and its relationship with tumor hypoxia using dynamic contrast-enhanced CT and 18F-misonidazole PET in murine tumor models. Sho Koyasu, Yoshihisa Tsuji, Hiroshi Harada, Yuji Nakamoto, Tomomi Nobashi, Hiroyuki Kimura, Kohei Sano, Koji Koizumi, Masatsugu Hamaji, Kaori Togashi. Radiology, 278(3):734-741 (2016)
  11. Synthesis and evaluation of a new vesamicol analog o-[11C]methyl-trans-decalinvesamicol as a PET ligand for the vesicular acetylcholine transporter. Yoji Kitamura, Takashi Kozaka, Daisuke Miwa, Izumi Uno, Mohammad Anwar-Ul Azim, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Kazuhiro Shiba. Annals of Nuclear Medicine, 30, 122-129 (2016), 10.1007/s12149-015-1039-6.
  12. In vivo differences between two optical isomers of radioiodinated o-iodo-trans-decalinvesamicol for use as a radioligand for the vesicular acetylcholine transporter. Izumi Uno, Takashi Kozaka, Daisuke Miwa, Yoji Kitamura, Mohammad Anwarul Azim, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Kazuhiro Shiba, PLoS One, 11, e0146719/1-e0146719/14 (2016), 10.1371/journal.pone.0146719.
  13. Evaluation of Chlorella as a decorporation agent to enhance the elimination of radioactive strontium from body. Kazuma Ogawa, Tadahisa Fukuda, Jaegab Han, Yoji Kitamura, Kazuhiro Shiba, Akira Odani. PLoS One, 11, e0148080/1-e0148080/10 (2016), 10.1371/journal.pone.0148080.
  14. Synthesis and evaluation of a new vesamicol analog o-[11C]methyl-trans-decalinvesamicol as a PET ligand for the vesicular acetylcholine transporter. Yoji Kitamura, Takashi Kozaka, Daisuke Miwa, Izumi Uno, Mohammad Anwar-Ul Azim, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Kazuhiro Shiba. Annals of Nuclear Medicine, 30, 122-129 (2016), 10.1007/s12149-015-1039-6.
  15. In vivo differences between two optical isomers of radioiodinated o-iodo-trans-decalinvesamicol for use as a radioligand for the vesicular acetylcholine transporter. Izumi Uno, Takashi Kozaka, Daisuke Miwa, Yoji Kitamura, Mohammad Anwarul Azim, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Kazuhiro Shiba, PLoS One, 11, e0146719/1-e0146719/14 (2016), 10.1371/journal.pone.0146719.
  16. Evaluation of Chlorella as a decorporation agent to enhance the elimination of radioactive strontium from body. Kazuma Ogawa, Tadahisa Fukuda, Jaegab Han, Yoji Kitamura, Kazuhiro Shiba, Akira Odani. PLoS One, 11, e0148080/1-e0148080/10 (2016), 10.1371/journal.pone.0148080.

国際及び国内学会発表

  1. Hiroyuki Kimura, Haruka Okuda, Kenji Arimitsu, Akira Makino, Ryuichi Nishii, Anna Miyazaki, Hiroyuki Watanabe, Masahiro Ono, Hideo Saji. （ポスター）Development of a PET imaging probe for discrimination of secondary mutation in the epidermal growth factor receptor. Society of Nuclear Medicine and Molecular Imaging 2016 Annual Meeting (San Diego, USA). 2016.6.11-15
  2. Akira Makino, Anna Miyazaki, Hiroyuki Kimura, Masahiko Hirata, Yoshiro Ohmomo, Ryuichi Nishii, Hidehiko Okazawa, Yasushi Kiyono, Masahiro Ono, and Hideo Saji. （ポスター）Development of a PET probe detecting tumors, which are responsive to gefitinib treatment. Society of Nuclear Medicine and Molecular Imaging 2016 Annual Meeting (San Diego, USA). 2016.6.
  3. 松岡大航，木村寛之，原田直弥，三平崇太郎，渡邊裕之，小野正博，佐治英郎．Development of 99mTc-labeled asymmetric urea derivatives targeting prostate specific membrane antigen for prostate cancer imaging．第26回金属の関与する生体関連反応シンポジウム(北海道)，2016.6.
  4. 初川雄一，塚田和明，橋本和幸，佐藤哲也，浅井雅人，豊嶋厚史，永井泰樹，谷森　達，園田伸也，株木重人，木村寛之，高田淳史，水本哲也，早川岳人．（ポスター）コンプトンカメライメージング用Tc-95m及びTc-96生成研究．2016日本放射化学会年会・第60回放射化学討論会(新潟)，2016.9.
  5. 石黒真澄，奥田　悠，有光健治，木村寛之，髙瀨里紗，牧野　顕，内本ひとみ，繁田　尭，小野正博，佐治英郎，川崎郁勇．（ポスター）EGFRチロシンキナーゼを標的とした18F標識pyrido[3,4-d]pyrimidine誘導体の合成と評価．第66回日本薬学会近畿支部総会・大会(大阪), 2016.10.
  6. 石黒真澄，奥田　悠，有光健治，木村寛之，髙瀨里紗，牧野 顕，内本ひとみ，繁田 尭，小野正博，佐治英郎，川崎郁勇．（ポスター）上皮成長因子受容体（EGFR）の遺伝子変異の識別を目的とした18F標識分子イメージングプローブの開発. 第34回メディシナルケミストリーシンポジウム(茨城)，　2016.11-12.
  7. 古川武典，木村寛之，有光健治，安井裕之．（ポスター）RI-NEXTA反応を用いた新規18F標識法の開発．第6回4大学連携研究フォーラム(京都)，2016.12.

シンポジウム、ワークショップ及び講演

  1. 木村寛之．（講演・口頭）：分子イメージング技術を用いた新しい診断法の開発．第7回KPUシンポジウム(京都)，2016.4.
  2. 木村寛之．（講演・口頭）：臨床応用を目指した腫瘍イメージングプローブの開発研究．創薬科学フロンティア研究センター講演会(京都)，2016.3.
  3. 木村寛之．（講演・口頭）：PET化学 ISRS2015 報告その1「5. 自動合成装置」．PET化学ワークショップ2016(兵庫)，2016.2.
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