お問い合わせ

2017年

業績目録

原著

  1. Obesity-promoting and anti-thermogenic effects of neutrophil gelatinase-associated lipocalin in mice. Akira Ishii, Goro Katsuura, Hirotaka Imamaki, Hiroyuki Kimura, Keita P. Mori, Takashige Kuwabara, Masato Kasahara, Hideki Yokoi, Kousaku Ohinata, Tomoko Kawanishi, Junichi Tsuchida, Yuji Nakamoto, Kazuwa Nakao, Motoko Yanagita, Masashi Mukoyama, Kiyoshi Mori. Scientific Reports, 7: 15501 (2017)
  2. Absolute configuration of eight cephalimysins isolated from the marine-derived Aspergillus fumigatus. Takeshi Yamada, Hiroyuki Kimura, Kenji Arimitsu, Tetsuya Kajimoto, Takashi Kikuchi, Reiko Tanaka. Chemistry Select, 2(33), 10936-10940 (2017)
  3. Synthesis and evaluation of a novel near-infrared fluorescent probe based on succinimidyl-Cys-C(O)-Glu that targets prostate-specific membrane antigen for optical imaging. Daiko Matsuoka, Hiroyuki Watanabe, Yoichi Shimizu, Hiroyuki Kimura, Masahiro Ono, and Hideo Saji. Bioorganic & Medicinal Chemistry Letters, 27(21), 4876-4880 (2017)
  4. Synthesis and biological evaluation of an 111In-labeled exendin-4 derivative as a single-photon emission computed tomography probe for imaging pancreatic β-cells. Hiroyuki Kimura*, Naotaka Fujita, Kaori Kanbe, Hirokazu Matsuda, Hiroyuki Watanabe, Kenji Arimitsu, Hiroyuki Fujimoto, Keita Hamamatsu, Yusuke Yagi, Masahiro Ono, Nobuya Inagaki, Hideo Saji. Bioorganic & Medicinal Chemistry, 25(20), 5772-5778 (2017)
  5. Development of a local anesthetic lidocaine-loaded redox-active injectable gel for postoperative pain management. Yukio Nagasaki, Yutaro Mizukoshi, Zhenyu Gao, Chitho P. Feliciano, Kyungho Chang, Hiroshi Sekiyama, Hiroyuki Kimura. Acta Biomaterilalia, 57, 127-135 (2017)
  6. Long-term bioavailability of redox nanoparticles effectively reduces organ dysfunctions and death in whole-body irradiated mice. Chitho P. Feliciano, Koji Tsuboi, Kenshi Suzuki, Hiroyuki Kimura, Yukio Nagasaki. Biomaterials, 129, 68-82 (2017)
  7. Aggregation is a critical cause of poor transfer into the brain tissue of intravenously-administered cationic PAMAM dendrimer nanoparticles. Yoshika Kurokawa, Hideko Sone, Tin-Tin Win-Shwe, Yang Zeng, Hiroyuki Kimura, Yosuke Koyama, Yusuke Yagi, Yasuto Matsui, Masashi Yamazaki, Seishiro Hirano. International Journal of Nanomedicine, 12, 3967-3975 (2017)
  8. Development of Gd3N@C80 encapsulated redox nanoparticles for high-performance magnetic resonance imaging. Zhenyu Gao, Yusuke Nakanishi, Shoko Noda, Haruka Omachi, Hisanori Shinohara, Hiroyuki Kimura, Yukio Nagasaki. Journal of Biomaterials Science: Polymer Edition, 28, 1036-1050 (2017)
  9. 18F-Labeled 4-(anilino)pyrido[3,4-d]pyrimidine as an effective imaging probe targeting L858R-mutant epidermal growth factor receptor. Hiroyuki Kimura*, Haruka Okuda, Masumi Ishiguro, Kenji Arimitsu, Akira Makino, Ryuichi Nishii, Anna Miyazaki, Yusuke Yagi, Hiroyuki Watanabe, Ikuo Kawasaki, Masahiro Ono, and Hideo Saji. ACS Medicinal Chemistry Letters, 8(4), 418-422 (2017)
  10. Development of 111In-labeled exendin(9-39) derivatives for single-photon emission computed tomography imaging of insulinoma. Hiroyuki Kimura*, Hirokazu Matsuda, Yu Ogawa, Hiroyuki Fujimoto,　Kentaro Toyoda, Naotaka Fujita, Kenji Arimitsu, Keita Hamamatsu, Yusuke Yagi, Masahiro Ono, Nobuya Inagaki, Hideo Saji. Bioorganic & Medicinal Chemistry, 25(4), 1406-1412 (2017)
  11. Evaluation of Ga-DOTA-(D-Asp)n as bone imaging agents: D-aspartic acid peptides as carriers to bone. Kazuma Ogawa, Atsushi Ishizaki, Kenichiro Takai, Yoji Kitamura, Akira Makino, Takashi Kozaka, Yasushi Kiyono, Kazuhiro Shiba, Akira Odani. Scientific Reports, 7, 1-11 (2017), 10.1038/s41598-017-14149-7.
  12. Synthesis and evaluation of radioiodinated 1-{2-[5-(2-methoxyethoxy)-1H-benzo[d]imidazol-1-yl]quinolin-8-yl}piperidin-4-amine derivatives for platelet-derived growth factor receptor β (PDGFRβ) imaging. Nurmaya Effendi, Kazuma Ogawa, Kenji Mishiro, Takeshi Takarada, Daisuke Yamada, Yoji Kitamura, Kazuhiro Shiba, Takehiko Maeda, Akira Odani. Bioorganic & Medicinal Chemistry, 25, 5576-5585 (2017), 10.1016/j.bmc.2017.08.025.

著書

  1. 臨床放射薬学　薬学領域における放射化学の理論と実践, 河嶋秀和，木村寛之 編著, 京都廣川書店 (2017)
    第1編：第1章「医療におけるradiopharmacistの現状と未来」，第2編：第2章「医療における放射線の利用」，第3章「画像診断法」，第4章「放射性医薬品」，第5章「放射線の生体への影響」，第6章「放射線および放射性物質の管理と安全取扱い」，第3編：第11章「放射線の生命科学領域における利用」の執筆と全体の編集を担当。現在3つの大学において教科書として採用されている。

国際及び国内学会発表

  1. 木村寛之，古川武典，有光健治，戸田力也，河嶋秀和，安井裕之，佐治英郎，瀧　真清．（ポスター）NEXTA反応を用いた18F-ペプチド標識法の開発とPETプローブへの応用．第40回フッ素化学討論会(鳥取)，2017年11月14日，15日
  2. 木村寛之，河嶋秀和，有光健治，屋木祐亮，川崎保弘，平野圭市，表 正宏，安井裕之．（口頭）放射性医薬品に関する薬学生の意識調査とデモ実習への取り組み．第2回日本薬学教育学会大会 (愛知)，2017年9月2日，3日
  3. Hiroyuki Kimura, Yusuke Yagi, Kenji Arimitsu, Kazuya Maeda, Shinya Kagawa, Masahiro Ono, Hiroyuki Kusuhara, Yuichi Sugiyama, and Hideo Saji. （ポスター）Synthesis and evaluation of [18F]PTV-F1 as a tracer for hepatic organic anion transporting polypeptide. 22nd International Symposium on Radiopharmaceutical Sciences (Dresden, Germany). 2017.5.14-19

シンポジウム、ワークショップ及び講演

  1. 木村寛之．（講演・口頭）：ユニットカップリング型分子プローブの開発戦略．創薬科学フロンティア研究センター講演会(京都)，2017.2.
  2. 木村寛之．（講演・口頭）：PSMAを標的とした前立腺がん用イメージングプローブの開発と臨床応用. 第13回小動物インビボイメージング研究会(大阪)，2017.7.
  3. 木村寛之．（講演・口頭）：18F-PETプローブの迅速合成法の開発．JSPS第155委員会主催講演会　平成29年度第１回「フッ素と医療の研究最前線」(群馬), 2017.12.
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