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2021年

業績目録(木村 寛之)

原著

  1. Development of Novel Radioiodinated Exendin-4 Derivatives Targeting GLP-1 Receptor for Detection of β-cell Mass. Yu Ogawa, Hiroyuki Kimura*, Hiroyuki Fujimoto, Hidekazu Kawashima, Kentaro Toyoda, Eri Mukai, Yusuke Yagi, Masahiro Ono, Nobuya Inagaki, and Hideo Saji. Bioorganic & Medicinal Chemistry, 52, 116496(2021)
  2. First-In-Human Evaluation of Positron Emission Tomography/Computed Tomography with [18F]FB(ePEG12)12-Exendin-4: A Phase 1 Clinical Study Targeting Pancreatic Beta Cells. Hiroyuki Fujimoto, Naotaka Fujita, Keita Hamamatsu, Takaaki Murakami, Yuji Nakamoto, Tsuneo Saga, Takayoshi Ishimori, Yoichi Shimizu, Hiroyuki Watanabe, Norio Harada, Hiroshi Nakamura, Kentaro Toyoda, Hiroyuki Kimura, Mitsuharu Hirai, Atsushi Murakami, Masahiro Ono, Kaori Togashi, Hideo Saji, Nobuya Inagaki. Frontiers Endocrinology, 12,717101(2021)
  3. Distinctive Detection of Insulinoma using [18F]FB(ePEG12)12-Exendin-4 PET/CT. Takaaki Murakami, Hiroyuki Fujimoto, Keita Hamamatsu, Yuki Yamauchi, Yuzo Kodama, Naotaka Fujita, Junji Fujikura, Yoichi Shimizu, Yuji Nakamoto, Hiroyuki Kimura, Hideo Saji, Nobuya Inagaki. Scientific Reports, 11(1), 15014 (2021)
  4. A putative single-photon emission CT imaging tracer for erythropoietin-producing hepatocellular A2 receptor. Takenori Furukaw, Hiroyuki Kimura*, Hanae Torimoto, Yusuke Yagi, Hidekazu Kawashima, Kenji Arimitsu, Hiroyuki Yasui. ACS Medicinal Chemistry Letters, 12(8), 1238-1244 (2021)
  5. Strong binding affinity of D-allulose and allulosides to boronic acids and the structural characterization of their sugar-boronate complexes. Kenji Arimitsu, Hiroki Iwasaki, Hiroyuki Kimura, and Hiroyuki Yasui. Chemistry Letters, 50(8), 1470–1474 (2021)
  6. Copper-mediated radioiodination reaction through aryl boronic acid or ester precursor and its application to direct radiolabeling of a cyclic peptide. Yuto Kondo, Hiroyuki Kimura*, Chiaki Fukumoto, Yusuke Yagi, Yasunao Hattori, Hidekazu Kawashima, Hiroyuki Yasui. Journal of Labelled Compounds and Radiopharmaceuticals, 64(8), 336 – 345 (2021). doi.org/10.1002/jlcr.3925
  7. Automatic radioisotope manipulation for small amount of nuclear medicine using an EWOD device with a dimple structure. Katsuo Mogi, Hiroyuki Kimura, Yuto Kondo, Tomoya Inoue, Shungo Adachi, Tohru Natsume. Royal Society Open Science, 8(5): 201809 (2021). doi.org/10.1098/rsos.201809
  8. Aicardi-Goutieres syndrome-like encephalitis in mutant mice with constitutively active MDA5. Hideo Onizawa, Hiroki Kato, Hiroyuki Kimura, Tomoo Kudo, Nobumasa Soda, Shota Shimizu, Masahide Funabiki, Yusuke Yagi, Yuji Nakamoto, Josef Priller, Ryuta Nishikomori, Toshio Heike, Nan Yan, Tohru Tsujimura, Tsuneyo Mimori, Takeshi Fujita. International Immunology, 33(4), 225-240 (2021)
  9. In vitro and in vivo evaluation of [125/123I]-2-[4-(2-iodophenyl)piperidino]cyclopentanol ([125/123I]-OI5V) as a potential sigma-1 receptor ligand for SPECT. Taiki Shigeno, Takashi Kozaka, Yoji Kitamura, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Kazuhiro Shiba. Annals of Nuclear Medicine, 35, 167-175 (2021), 10.1007/s12149-020-01552-w.
  10. Visualization of dynamic expression of myocardial sigma-1 receptor after myocardial ischemia and reperfusion using radioiodine-labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) imaging. Hiroshi Wakabayashi, Junichi Taki, Hiroshi Mori, Tomo Hiromasa, Norihito Akatani, Anri Inaki, Takashi Kozaka, Kazuhiro Shiba, Kazuma Ogawa, Seigo Kinuya. Circulation Journal, 85, 2102-2108 (2021), 10.1253/circj.cj-21-0320.
  11. 68Ga- and 211At-Labeled RGD Peptides for Radiotheranostics with Multiradionuclides. Kazuma Ogawa, Hiroaki Echigo, Kenji Mishiro, Saki Hirata, Kohshin Washiyama, Yoji Kitamura, Kazuhiro Takahashi, Kazuhiro Shiba, Seigo Kinuya. Molecular Pharmaceutics, 18, 3553-3562 (2021), 10.1021/acs.molpharmaceut.1c00460.

国際及び国内学会発表

  1. 木村寛之：「18F標識法について」.  第10回フッ素化学若手の会 (オンライン), 2021.09.
  2. Hiroyuki Kimura: Synthesis of 18F-labeled streptozotocin derivatives and in vivo kinetics using positron emission tomography.  2021 CSPS/PSJ/CC-CRS SYMPOSIUM (Canada), 2021.06.
  3. 小阪孝史, 北村陽二, 柴 和弘.（英語・口頭）Development of PET/SPECT probes for Vesicular acetylcholine transporter (VAChT) imaging. 第61回日本核医学会学術総会, 核医学会シンポジウム（名古屋）, 2021年11月4日.

シンポジウム、ワークショップ及び講演

  1. 木村寛之（講演・口頭）：「18F標識法について」.第10回フッ素化学若手の会 (オンライン), 2021.09.
  2. Hiroyuki Kimura．（講演・口頭）: Synthesis of 18F-labeled streptozotocin derivatives and in vivo kinetics using positron emission tomography.  2021 CSPS/PSJ/CC-CRS SYMPOSIUM (Canada), 2021.06.
  3. 木村寛之．（講演・口頭）：「薬学から宇宙を目指す！～視点を変えれば、研究はもっと広がる～」.  KPU Academic Talk Vol.1 (京都), 2021.11.
  4. 木村寛之．（講演・口頭）：「放射性医薬品概論：自動合成化の必要性について」.  一関工業高等専門学校 課題解決型地域インターンシップ (オンライン), 2021.10.
  5. 木村寛之．（講演・口頭）：「放射性医薬品の自動合成化とロボットの活用について」.  TOLICインターンシップ (オンライン), 2021.08.

その他の印刷物(解説、プロシーディング等)

プロシーディング

  1. Shotaro Komura, Tetsuya Mizumoto, Takashi Minami, Yoshinori Sakurai, Natsuko Kondo, Minoru Suzuki, Takushi Takata, Hiroyuki Kimura, Toru Tanimori, Atsushi Takada. Establishment of quantitative Measurement of boron concentration distribution in vivo by imaging of prompt gamma rays. KURNS Progress Report 2020, 85 (2021)
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